There are also a lot of theories about the collapse of the mongol empire(s). The ilkhanate (persia and anatolia) and the golden horde were very stable, with basically two borders separating Beijing and Byzantium and all the benefits that came from that. When those two states broke up it turned the near and middle east into a decentralised mess, where almost every state was a military junta and war was endemic -- hardly ideal for trade or innovation. Among other things it pushed trade out to sea and the region never recovered.
The Ottomans exacerbated the problem by allowing their economy to be exploited in the same silver-based mercantile scam that western europe pulled on the entire rest of the world.
Islam was also going through a bit of a political upheaval in the late 1300s. The great polymaths and scientists you got in al-andalus were becoming less common due to a lack of sponsors, and (sunni) Islam's new focus on theology put the golden age of arab and persian science to rest.
The Ottomans exacerbated the problem by allowing their economy to be exploited in the same silver-based mercantile scam that western europe pulled on the entire rest of the world.
Islam was also going through a bit of a political upheaval in the late 1300s. The great polymaths and scientists you got in al-andalus were becoming less common due to a lack of sponsors, and (sunni) Islam's new focus on theology put the golden age of arab and persian science to rest.