Heh...forget any major publishers then...if I guess right, they'd not even dare considering financing this game in any way...
Maybe if one could talk them into having this game as a "minor" release or something, cause frankly, a two-man team won't have too much success in convincing a big publisher...some small-scale one perhaps, but then of course, the release will be quite limited...
Add on top that any profit that would be made; part of it would go to the publishers instead of armagon, which would mean that there'd be a need to jack up the price for the game up considerably...
Even worse, there would be a time pressure as there is the risk that publishers might demand release dates and such...
No, best way to distribute a game so far is the way it's done now, build up income and reputation in the process...and not rely on publishers...yet...
Overal, I have a dislike for any publishers...sure, they print manuals and pretty boxes and all, but they also hog up profits etc...game makers should find ways to circumvent publishers for many many reasons...