Tons
What kind of game are you looking for exactly? What about specs?
At the moment I'd recommend:
Pathologic - Bleak survivalist horror from Russia. The basic schtick is you're visiting a village in the arse end of nowhere which ends up being quarrantined due to a mysterious plague outbreak. You get twelve days to discover the cure. What makes it particularly interesting is that the three different characters you can play all move through the same story but from their own perspective, so you will for example be arrested for unfathomable reasons as one character, only to find out why when you play through as another. It's ostensibly an FPS, although not combat oriented, and the sketchy translation runs from bat**** craziness to the amazingly poetic. RPS have a good breakdown
here, though be warned it does contain some spoilers. Oh, and the game was made in 2005 so the graphics aren't top notch, but they are incredibly effective in terms of atmosphere.
AI War - Fleet Command An indie RTS in space with your opponent being one (or more) nefarious AI constructs. Multiplayer is co-op, basically you and your friends versus the massive AI empire. It uses some interesting mechanics to keep it interesting, for example how the AI responds to you is based on a threat level which increases when you attack systems, and decreases if you destroy certain structures. It therefore plays to take a strategic approach to the game and plan your raids and attacks with an eye on manipulating the AI to avoid having it crush you like a bug (I did mention it starts out controlling every system but the one you get, right?). Again, graphics are nothing fancy but then it is an indie game.
Gratuitous Space Battles - I've posted about it before. Another indie game, you get to design ships and pit them against opposing fleets. You can't control any of the ships in the battle, but you can set initial orders, formations and the like.
Far Cry 2 If you haven't got it yet, £13 from Impulse with the fortune DLC included. Free roaming FPS in Africa with slight literature pretensions. Amazing fire effects, good themes but definitely one of those games you'll either love or hate depending on how you approach it.
Warlords Battlecry III RTS. 2D graphics, similar to Warcraft 3 (although it predates it. In fact, Blizzard probably lifted half their stuff from it) except with persistent hero and more options regarding race, class and abilities than you can shake a very pointy stick at. Nice campaign method which basically lets you roam a map and take on the missions you want, there's some bollocks about a portal to hell or something offered up as a plot, but why bother when you can just go and slaughter the Lizardmen instead. Definitely worth while if you've ever played WC3 and wished it could be a little more complex.