I've never istalled a single mod. I've played the game since EA released, more than 300 hours with only few random crash. After 1.4.3 and refactoring, it just crash after char creation, or after contrast or brightness settings selected if I choose to launch the game in safe modeHave you installed a mod called Fixed Launcher? If so please remove it and try again. There are some reports from the forums that some players have experienced the same shader issue and it got resolved after they removed that modification.
But, we are aware of the Shader issue and currently, our engine team is investigating this issue on our end as well.