Of course. But that's normally viewed as some form of regentship -- which people can make a legit argument that it's not really 'femals being lords." However, the interesting bit is that even without counting in female regents, females did ascend to lordship and queenship actually without much problems, because although the traditions differed between regions, female inheritance wasn't something that was fundamentally made impossible or anything. In most cases the law of inheritance did prioritize male heirs over females, but when there were no males? The female heiress naturally ascended.
And surely, through about 1,000 years of Medieval ages (in the wide sense), PLENTY of noble houses met such situations -- and no, bringing in outside son-in-law to marry the female heiress, does not mean that son-in-law inherited the House.
As a matter of fact, the whole weakening of the French crown and the subsequent dynastic crisis of France that led to the 100 years war, began when Philippe of Poitier made a stunt to try and bar females from inheriting the crown. After the death of Louis X, there wasn't a precedence of a Queen in France, but people didn't particularly see a problem with a Queen on the throne. Philippe challenged that notion, and consequentially dragged in the long-dead Salic laws to force his position to disqualify a female from the French throne.
Then came the irony, that when Philippe himself died, his House met the exact same situation where Philippe had no male heirs, and only females. His enemies used the exact same argument to disqualify the female heirs from the throne... and this meant there was a huge confusion in succession as to whom the crown should go...
...and lo and behold, the English royal family, that had ties with the French through isabelle of France, now got entangled in the mess.
So, trying to stop female inheritance, was actually abnormal, because Philippe's citation of the Salic laws caused a huge controversy back then, because many argued it was a long-dead law not in use, and therefore invalid.