What to take on main character? Let's see:
Vigor and Control skills: All combat skills do nothing for late game, they can be 100% ignored without any significant loss in power. Bow or Crossbow skill somewhat useful to make few kills on sieges, but this is it.
Athletics skills: Riding good to have at 225. more not needed. Athletics and Smithing not needed at all on main character.
Cunning skills: Scouting good to have at 225, getting more is waste of time, attribute and focus points. Tactics is actually useful for late game, there you grind army after army and siege after siege. Saves a lot of time. Getting to 275+ is too slow to really aim for it. Roguery is a waste of time, some perks are nice, but leveling it up is such pain in the butt - not worth it.
Social skills: Charm is must have for late game character, 275 perk is insanely good and for a change it is not hard to get. Leadership is great for late game king/vassal, useful perks and main skill effect.Trade, hmmm, Trade is a waste of time, doing absolutely nothing to gameplay and leveling it is chore of nightmares.
Intellectual skills. Steward, Surgeon and Engineer useful for late game. Sure, they can be outsourced. but why? Why risk loosing your 330 skill quartermaster or high level surgeon? To free some focus points and put them into useless combat skills you'll never use past very early game?
This is all lead to boring, but effective 2 Vigor, 2 Control, 3 Athletics, 3 Cunning, 7 Social, 7 Intelllect builds. Very suitable for miind numbling late game experience .