Hmm....i know i have mostly medium , textures and characters are on high , shadows are low , vsync on and game capped to 61 fps fullscreen , SSAO and AntiAliasing off and the other check boxes like tesselation or bloom are either on /off (cant remember right now).
The game runs at 50-60 fps no problem , is the RAM getting full after a while that leads to stuttering , this is why no matter the game settings people experience it.