What specific part? I'm not as familiar with that period, my memories were that it was mostly a succession of empires centered around Mesopotamia, swapping between Babylonians, Assyrians, Hitties, and Persians over a span of a thousand years or so.
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Personally, I would prefer a new game set in the Warring States period in China, or the 30 years war. Total War really is at its best when focusing on a short time period.