Solved the problem. IT was because I was playing around with my save file, trying to remove some lines to avoid the "Gang leader requests x weapons" causing crashes when leaving inventory. Once I removed the save file in question, it resolved.I played 7h and no big problem, I loaded my game and played it. But now I can't use it anymore. I can go in "campaign" and start a new one, "options", ... but I cant load old ones. Even in safe mode. I tried the steps pinned for crashes at launch, it didn't change anything.
500-1000 GB graphic save space.