How does macro make blocking easier? You can make a key for every block direction but then have to memorize the keys and still hit them in the right sequence. I find it much easier just to learn how to do it manually. The one exception is attack chaining, I have played vs some people in MP that seem to have attacks at a machine gun pace- faster than any Champion bot I faced in SP- no idea how they are doing that.
The attacks aren't spammed from a single direction either but left, over, left, right, etc. I could see a macro making a huge difference there. Just keep your avatar moving in while the attacks chain- you can interrupt to block if you mess up but usually once you get into a flow that stun/knocks the other player into guard mode you got a guaranteed kill 1 v 1.